Chelation-assisted de-aryloxylative amination of 2-aryloxy quinolines: a new synthetic route to a key fragment of a bioactive PRMT5 inhibitor was written by Gupta, Aniket;Kumar, Jogendra;Bhadra, Sukalyan. And the article was included in Organic & Biomolecular Chemistry in 2018.Category: bromides-buliding-blocks This article mentions the following:
A highly regioselective de-aryloxylative amination of O- or N-chelating group-functionalized 2-aryloxy quinolines was accomplished by means of a copper catalyst. The chelating functional groups of the substrate played a crucial role in directing the C-2-selective amination process, which was proceeded through a novel aromatic nucleophilic substitution of the aryloxy group. The methodol. provided expedient access to an important class of functionalized 2-aminoquinolines I [R = NMe2, piperidinyl, N(Bn)2, etc.; R1 = H, 5-F, 5-Cl, 5-Br, 5-Me, 5-OMe; R2 = OH, NHTs, NHC(O)Me, etc.] (up to 88% isolated yield) and was successfully applied for the synthesis of a key fragment of an important bioactive PRMT5 inhibitor I [R = morpholinyl; R1 = H; R2 = OCH2C(O)OEt]. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Category: bromides-buliding-blocks).
2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary