Synthesis of symmetrical cyclodextrin derivatives bearing multiple charges was written by Guillo, Frederique;Hamelin, Bertrand;Jullien, Ludovic;Canceill, Josette;Lehn, Jean-Marie;De Robertis, Laurence;Driguez, Hugues. And the article was included in Bulletin de la Societe Chimique de France in 1995.Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:
Several water-soluble sym. cyclodextrin derivatives bearing pos. charged or neg. charged groups were synthesized to examine the possibility of obtaining stable electrostatically linked hetero-dimers in water. The pos. charged species were obtained from per-amino functionalization of the 6-glucose positions, whereas the neg. units were obtained through introduction of thioglycolate or glycolate groups at the 6- or 3-glucose positions. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).
Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary