Synthesis of HIV NNRTI Doravirine Analogues via Visible-Light Photoredox Decarboxylative Cross-Coupling was written by Suen, Linda M.;Wang, Cheng;Hunter, David N.;Mitchell, Helen J.;Converso, Antonella;ElMarrouni, Abdellatif. And the article was included in Synthesis in 2018.Safety of Methyl 4-bromo-2-fluorobenzoate This article mentions the following:
A C(sp 2)-C(sp 3) decarboxylative cross-coupling reaction utilizing dual nickel and photoredox catalysis for rapid parallel synthesis of diverse C-ring analogs of the HIV NNRTI clin. candidate doravirine is developed and described herein. This protocol features an alkylation with readily available and inexpensive Me bromoacetate followed by hydrolysis to prepare an advanced doravirine intermediate, which undergoes decarboxylative cross-coupling with a variety of aryl and heteroaryl bromides. The mildness, broad applicability, and sustainability of the current methodol. are improvements over previously reported procedures and allow for rapid parallel synthesis of analogs. The optimization and scope of this method are reported. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Safety of Methyl 4-bromo-2-fluorobenzoate).
Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Safety of Methyl 4-bromo-2-fluorobenzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary