The first chiral HPLC separation of dicarba-nido-undecarborate anions and their chromatographic behavior was written by Horacek, Ondrej;Papajova-Janetkova, Monika;Gruner, Bohumir;Lochman, Lukas;Sterbova-Kovarikova, Petra;Vespalec, Radim;Kucera, Radim. And the article was included in Talanta in 2021.Recommanded Product: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin This article mentions the following:
Boron cluster compounds are extensively studied due to their possible use in medicinal chem., mainly in the boron neutron capture anticancer therapy and as new innovative pharmacophores. Concerning this research, the chiral separations of exceptionally stable anionic 7,8-dicarba-nido-undecaborate(1-) and metal bis(dicarbollide)(1-) derivatives with asym. substitutions remain the unsolved challenge of the chiral chromatog. nowadays. Although the successful enantioseparation of some anionic 7,8-dicarba-nido-undecaborate(1-) ion derivatives were achieved in CZE with native β-cyclodextrins, it has not been observed with HPLC, yet. This study aimed to systematically investigate the enantioseparation of selected compounds in HPLC using native β-cyclodextrin and brominated β-cyclodextrin. The findings revealed pos. charged strong adsorption sites on a stationary phase, identified as the cationic metal impurities in the silica-gel backbone. All the anionic species under the study were at least partially enantiosepd. when a chelating agent blocked these cationic sites. Consequently, the first-ever HPLC enantioseparations of the 7,8-dicarba-nido-undecaborates(1-) were achieved. The brominated β-cyclodextrin seemed to be a better chiral selector for separation of these species, whereas the native β-cyclodextrin separated the anionic cobalt bisdicarbollide(1-). The results of this study bring new information concerning the chiral separation of anionic boron clusters and might be used in the chiral method development process on other chiral selectors. Furthermore, the possibility of chiral separation of these species could influence the ongoing research areas of anionic boron clusters. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Recommanded Product: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin).
Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary