Halogenation using quaternary ammonium polyhalides. XXIII. Bromination of aromatic amines with polymer-bound benzyltrimethylammonium tribromide was written by Okamoto, Tsuyoshi;Kakinami, Takaaki;Kusumoto, Masao;Yonemaru, Satoshi;Kajigaeshi, Shoji. And the article was included in Nippon Kagaku Kaishi in 1990.Electric Literature of C7H7BrN2O2 This article mentions the following:
Bromo-substituted aromatic amines were obtained quant. by passing a solution of aromatic amines in dichloromethane-methanol through a column packed with styrene polymer-bound benzyltrimethylammonium tribromide. E.g., 2,4,6-tribromoaniline (I) was obtained in 99% yield from aniline. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Electric Literature of C7H7BrN2O2).
2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Electric Literature of C7H7BrN2O2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary