Related Products of 630-17-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 630-17-1 as follows.
Preparation of 4-(3,5-dimethoxy-4-(neopentyloxy)benzyl)-7-ethoxyisoquinolin-8-ol hydrochloride 39 3,5-Dimethoxy-4-(neopentyloxy)benzaldehvde EMC 380484-Hydroxy-3,5-dimethoxybenzaldehyde (500 mg, 2.74 mmol) was dissolved in DMF (7.5 ml_) and CS2CO3 (894 mg, 2.74 mmol) and neopentyl bromide (456 mg, 3.02 mmol) were added at RT and the reaction was heated at 150C for 10 min under microwave irradiation. After cooling to RT, the reaction mixture was poured into water (75 ml_) and extracted by Et2O (50 ml_). The separated organic layer was washed with water (2×50 ml_), brine (50 ml_), dried over MgSO4, filtered and dried overnight under reduced pressure to give 3,5-dimethoxy-4-(neopentyloxy)benzaldehyde EMC 38048 (274 mg, 40% yield) as yellow oil. EMC 38048MW: 252.31 ; Yield: 40%; Yellow oil.1H-NMR (CDCIs, delta): 1 .05 (s, 9H, 3xCH3), 3.72 (s, 2H, OCH2), 3.90 (s, 6H, 2xOCH3), 7.12 (s, 2H, 2xArH), 9.85 (s, 1 H, CHO).13C-NMR (CDCIs, delta): 26.4 (3xC), 32.6, 56.4 (2xC), 83.7, 107.2 (2xC), 131 .3, 144.2, 153.8, 191 .2.MS-ESI m/z (% rel. Int.): 253 ([MH+], 20), 183 (100).HPLC: Method A, XBridge column, detection UV 254 nm, RT = 6.36 min, peak area 99.9%.
According to the analysis of related databases, 630-17-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; EXONHIT S.A.; LEBLOND, Bertrand; TAVERNE, Thierry; BEAUSOLEIL, Eric; CHAUVIGNAC, Cedric; CASAGRANDE, Anne-Sophie; DESIRE, Laurent; WO2011/151423; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary