Functionalized congener approach to muscarinic antagonists: analogs of pirenzepine was written by Karton, Yishai;Bradbury, Barton J.;Baumgold, Jesse;Paek, Robert;Jacobson, Kenneth A.. And the article was included in Journal of Medicinal Chemistry in 1991.Name: N-(5-Bromopentyl)phthalimide This article mentions the following:
(Piperazinylacetyl)pyridobenzodiazepinones I [R = Me, H, Ac, Bz, etc.; R1 = H, 8-SMe, 8-SO2NH2, 9-CH2OH, etc.; R2 = H, Et, (CH2)6CN] were prepared and examined as muscarinic receptor antagonists. Thus, 3-amino-2-chloropyridine underwent cyclocondensation with Me 2-aminobenzoate to give pyridobenzodiazepine II (R3 = H) which reacted with HOSO2Cl followed by S-methylation to give II (R3 = SMe) (III). III condensed with ClCH2COCl and 1-methylpiperazine to give I (R = Me, R1 = 8-SMe, R2 = H). Chain substitution at the C-8 or C-9 position essentially abolishes muscarinic receptor binding, whereas substitution of the endocyclic amide NH results in weak affinity. Further structure-activity relationship observations are discussed. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Name: N-(5-Bromopentyl)phthalimide).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Name: N-(5-Bromopentyl)phthalimide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary