Palladium-Catalyzed Intramolecular Aromatic C-H Acylation of 2-Arylbenzoyl Fluorides was written by Sakurai, Yuka;Ikai, Kana;Hayakawa, Kazuki;Ogiwara, Yohei;Sakai, Norio. And the article was included in Bulletin of the Chemical Society of Japan in 2021.Formula: C8H6BrFO2 This article mentions the following:
The catalytic intramol. cyclization of acyl fluorides using a Pd(OAc)2/PCy3 system was described for the synthesis of fluorenone precursors I [R = H, 5-Me, 5-F; R1 = 3-Me, 2-OMe, 2-Cl, etc]. A wide range of 2-arylbenzoyl fluoride derivatives could be used as fluorenone precursors and the reaction proceeded via an intramol. coupling between aromatic C-H bonds with acyl C-F bonds. The reaction could be applied to the synthesis of indenofluorenedione derivatives and to the construction of other mols. with five-membered rings. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Formula: C8H6BrFO2).
Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Formula: C8H6BrFO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary