Stereocontrolled Synthesis of Fluorinated Isochromans via Iodine(I)/Iodine(III) Catalysis was written by Hafliger, Joel;Sokolova, Olga O.;Lenz, Madina;Daniliuc, Constantin G.;Gilmour, Ryan. And the article was included in Angewandte Chemie, International Edition in 2022.Recommanded Product: 2-Bromo-4-(trifluoromethyl)benzaldehyde This article mentions the following:
The ubiquity of isochromans across the bioactive small mol. spectrum, the prominence of the anomeric effect in regulating conformation and the metabolic lability of the benzylic position, iodine(I)/iodine(III) catalysis was leveraged for the stereocontrolled generation of selectively fluorinated analogs. To augment the current arsenal of fluorocyclization reactions involving carboxylic acid derivatives, the reaction of readily accessible 2-vinyl benzaldehydes was disclosed (up to >95 : 05 d.r. and 97 : 03 e.r.). Key stereoelectronic interactions manifest themselves in the X-ray crystal structures of the products, thereby validating the [CH2-CHF] fragment as a stereoelectronic mimic of the [O-CH(OR)] acetal motif. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Recommanded Product: 2-Bromo-4-(trifluoromethyl)benzaldehyde).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 2-Bromo-4-(trifluoromethyl)benzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary