Synthesis of the biotinylated anti-HIV compound BMMP and the target identification study was written by Kamo, Masahiro;Tateishi, Hiroshi;Koga, Ryoko;Okamoto, Yoshinari;Otsuka, Masami;Fujita, Mikako. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Safety of N-(5-Bromopentyl)phthalimide This article mentions the following:
BMMP [2-(benzothiazol-2-ylmethylthio)-4-methylpyrimidine], an inhibitor of HIV-1 replication, was linked to biotin to study the interaction with the presumed target, HIV-1 Pr55Gag or CA, by means of surface plasmon resonance. The synthesized biotin-BMMP inhibited HIV-1 replication to a similar extent as BMMP alone, but did not interact with Pr55Gag or CA, suggesting that BMMP exerts its activity by a different mechanism. The synthesis of the target compound was achieved by a reaction of (3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid (biotin) with 2-[[(2-benzothiazolyl)methyl]thio]-4-pyrimidinehexanamine. The title compound thus formed was N-[[[[(benzothiazolyl)methyl]thio]pyrimidinyl]hexyl]biotinamide (biotin-BMMP). In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Safety of N-(5-Bromopentyl)phthalimide).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Safety of N-(5-Bromopentyl)phthalimide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary