Scope and limitations of lithium-ethylenediamine-THF-mediated cleavage at the α-position of aromatics: deprotection of aryl methyl ethers and benzyl ethers under mild conditions was written by Shindo, Takeyuki;Fukuyama, Yasuaki;Sugai, Takeshi. And the article was included in Synthesis in 2004.COA of Formula: C9H11Br This article mentions the following:
The scope and limitations of lithium-ethylenediamine-THF-mediated reductive bond cleavage at the α-position of aromatics were examined Very mild conditions such as lithium metal and ethylenediamine, in oxygen-free THF, were quite effective for the demethylation of aromatic ethers even at as low as -10°C. Allyl benzyl ethers were also deprotected under these conditions with very little change of the allylic alc. moiety. 2,6-Dimethylbenzyl ether was developed as an alternative to benzyl ether, which was readily cleaved under these conditions. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7COA of Formula: C9H11Br).
2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.COA of Formula: C9H11Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary