Solid-phase synthesis of phenols and pyridinones via arylboronation/oxidation protocol using aryl bromides was written by Lee, Younghee;Kelly, Martha J.. And the article was included in Tetrahedron Letters in 2006.Name: Methyl 3-bromo-5-hydroxybenzoate This article mentions the following:
A sequence of two known reactions, palladium-catalyzed arylboronation of aryl bromide and subsequent oxidation of arylboronate with oxone, has been carried out to prepare functionalized phenols and pyridin-2(1H)-one which were later loaded on to resin for solid-phase synthesis. Using these resin-bound templates, a number of solid-phase methods were developed to generate libraries of substituted phenols and pyridin-2(1H)-one. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Name: Methyl 3-bromo-5-hydroxybenzoate).
Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Methyl 3-bromo-5-hydroxybenzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary