Design, synthesis of some novel thiazolidin-4-one derivatives bearing benzimidazole nucleus and biological evaluation of their possible in vitro antiinflammatory as cyclooxygenase inhibitors and antioxidant activity was written by Sahoo, U.;Seth, A. K.;Balaraman, R.;Velmurugan, R.. And the article was included in Asian Journal of Chemistry in 2015.Application of 85118-24-7 This article mentions the following:
A series of 2-[2-(4-cyanophenyl)-6-substituted-1H-benzimidazol-1-yl]-N-[2-(substituted)-4-oxo-1,3- thiazolidin-3-yl]acetamide I (R1 = Cl, NO2; R2 = 4-H3COC6H4, 3-BrC6H4, 1H-pyrazol-3-ylphenyl, etc.) were synthesized. The substituted o-phenylenediamines were reacted with substituted 4-cyanobenzaldehydes in the presence of sodium metabisulfite to furnish substituted 2-(4-cyanophenyl)-1H-benzimidazoles II. The N-alkylated product (2-(4-cyanophenyl)-benzimidazol-1-yl)-acetic acid Et esters were obtained by the further treatment of substituted 2-(4-cyanophenyl)-1H-benzimidazoles with Et chloroacetate in KOH/DMSO. The chem. reactions were conducted between hydrazine hydrate and the esters to synthesize 2-(4-cyanophenyl)-benzimidazol-1-yl-acetic acid hydrazides. When a mixture of 2-(4-cyanophenyl)-benzimidazol-1-yl-acetic acid hydrazides reacted with substituted aldehydes in ethanol, imine intermediates were formed. The reactions between a mixture of imine intermediates and thioglycollic acid in dioxane resulted in the formation of the title compound I. All the synthesized compounds were screened for their in vitro antioxidant and antiinflammatory activity. The in vitro antioxidant and antiinflammatory activity might be attributed due to the presence of more electrons withdrawing group and moiety having more lipophilicity also more electronegativity in nature. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Application of 85118-24-7).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 85118-24-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary