Structure-Based Optimization of Benzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B and Low Molecular Weight Protein Tyrosine Phosphatase was written by Maccari, Rosanna;Ottana, Rosaria;Ciurleo, Rosella;Paoli, Paolo;Manao, Giampaolo;Camici, Guido;Laggner, Christian;Langer, Thierry. And the article was included in ChemMedChem in 2009.Formula: C8H7BrO2 This article mentions the following:
Protein Tyrosine Phosphatases comprise a large family of over 100 enzymes. Defective or inappropriate functioning of PTPs has been associated with many human pathologies, including diabetes,obesity and cancer.This communication concentrates on the focus of increasing interest of PTP’s as novel mol. targets in drug design. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Formula: C8H7BrO2).
3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C8H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary