N1,N1-Dimethyl-N3-(3-(trifluoromethyl)phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis was written by Pham, Ngoc B.;Deydier, Sophie;Labaied, Mehdi;Monnerat, Severine;Stuart, Kenneth;Quinn, Ronald J.. And the article was included in European Journal of Medicinal Chemistry in 2014.Application of 108940-96-1 This article mentions the following:
The natural product, convolutamine I, has anti-trypanosomal activity however it has a high mol. weight of 473 due to a presence of 3 bromine atoms. The synthesis of the natural product convolutamine I together with its analogs are presented. A SAR study against Trypanosoma brucei brucei led to compounds with improved physico-chem. properties: lower mol. weight and lower log P while maintaining potency (with a slight 2-fold improvement). In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Application of 108940-96-1).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application of 108940-96-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary