Organocatalytic Enantioselective Construction of Spiroketal Lactones Bearing Axial and Central Chirality via an Asymmetric Domino Reaction was written by Xu, Shiyu;Huang, Aima;Yang, Yang;Wang, Ying;Zhang, Ming;Sun, Zhihui;Zhao, Man;Wei, Yuanlin;Li, Guofeng;Hong, Liang. And the article was included in Organic Letters in 2022.Computed Properties of C4H4BrNO2 This article mentions the following:
The catalytic asym. synthesis of chiral compounds such as I [R = H, 7-Me, Ph, etc.; X = I, Br] with multiple stereogenic elements via a single catalytic process was challenging. This paper proposed a domino asym. electrophilic halocyclization strategy for constructing heterocycloalkenyl atropisomeric spiroketal lactones. A single catalyst was utilized to realize two independent stereodetermining steps. Various spiroketal lactones containing both chiral axes and chiral centers were prepared in excellent yields with excellent enantioselectivity and diastereoselective (up to 99% ee and >20:1 dr). In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Computed Properties of C4H4BrNO2).
1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C4H4BrNO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary