Formation of macrocyclic lactones in microemulsions was written by Gonzalez, Alvaro;Holt, Smith L.. And the article was included in Journal of Organic Chemistry in 1981.Quality Control of 15-Bromopentadecanoic acid This article mentions the following:
Macrocyclic lactones were prepared by using the reactants in detergentless microemulsions. A microemulsion of H2O, Me2CHOH, and PhMe was made 8 × 10-3M in 4-MeC6H4SO3H and treated with an identical microemulsion 1 × 10-2M in Me(CH2)5CH(OH)(CH2)10CO2H, HO(CH2)14CO2H, or HO(CH2)15CO2H over 2 h and the mixture heated at 65° 12 h to give 18-23% lactones I (R = benzyl, n = 10; R = H, n = 14, 15), 35-40% the iso-Pr esters, and 20% polymers. The above microemulsion was made 3 × 10-3M in Br(CH2)mCO2H (m = 10, 14) and an equivalent KOH added to form the K salt. This solution was heated at 65° 1 day to give 25 and 22% I (R = H, n = 9, 13) and 18 and 15% polymers. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Quality Control of 15-Bromopentadecanoic acid).
15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of 15-Bromopentadecanoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary