Ni-Catalyzed Larock Indenone Annulation with Aliphatic- and Silyl-Substituted Alkynes Supported by Mechanistic Analysis was written by Hynds, Hannah M.;Lemons, Holli E.;Willis, Jasmine D.;Bell, MarKayla J.;Bottcher, Sydney E.;Dye, Mei Lin N.;Echols, Emily T.;Garner, Edward L.;Hutchinson, Lauren E.;Phillips, Caleb M.;Stephens, Claudia P.;Gilbert, Thomas M.;Wilger, Dale J.. And the article was included in Organometallics in 2022.Product Details of 653-92-9 This article mentions the following:
A Ni-catalyzed annulation reaction to synthesize indenones is reported. The reaction provides high yields and regioselectivities when aliphatic- and silyl-substituted alkynes are employed. Both were challenging and underused substrate classes. Several mechanistic observations aided in the development of this reaction, including that β-hydride elimination is turnover-limiting for ortho-halogenated aldehyde substrates and that alkyne dissociation is rate-limiting for internal aliphatic alkynes. The authors anticipate that these methods will be rapidly adopted due to their synthetic ease and inherent versatility. The authors also anticipate that the mechanistic conclusions will inform further reaction development. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Product Details of 653-92-9).
Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 653-92-9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary