New caffeic acid phenylethyl ester analogs bearing substituted triazole: synthesis and structure-activity relationship study towards 5-lipoxygenase inhibition was written by Roy, Pierre-Philipe;Faye, Diene;Blanchard, Sebastien;Cormier, Marc;Doiron, Jeremie A.;Surette, Marc E.;Touaibia, Mohamed. And the article was included in Journal of Chemistry in 2017.SDS of cas: 14425-64-0 This article mentions the following:
Sixteen new CAPE analogs bearing substituted triazole were synthesized by copper catalyzed Huisgen 1,3-dipolar cycloaddition Compound I (R = 4-CF3C6H4) was equivalent to CAPE but clearly surpassed Zileuton, the only approved 5-LO inhibitor. Substitution of the phenethyl moiety by cyclohexylethyl, as with I (R = cyclohexyl), clearly increased 5-LO inhibition which confirms the importance of hydrophobic interactions. Mol. docking revealed new hydrogen bonds and π-π interactions between the enzyme and some of the investigated compounds In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0SDS of cas: 14425-64-0).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.SDS of cas: 14425-64-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary