Related Products of 630-17-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 630-17-1 name is 1-Bromo-2,2-dimethylpropane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5-Bromo-2-hydroxy-1-cyanobenzene (1.0 g, 5.0 mmol) was dissolved in DMF (10 mL), add K2CO3 (2.1 g, 15.0 mmol), stir at room temperature for 1.0 h, add bromo neopentane (2.3 g, 15.0 mmol), and react at 80 C for 3 h.TLC followed the reaction completely. It was cooled to room temperature, diluted with 100 mL of water, and extracted with ethyl acetate (100 mL¡Á3), purified by silica gel column chromatography (ethyl acetate V: V petroleum ether = 1: 20) to give 5-bromo-2-neopentyloxybenzonitrile (a5)1.22 g, yield 90%
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2,2-dimethylpropane, and friends who are interested can also refer to it.
Reference:
Patent; South China University of Technology; Li Jing; Li Xiaolei; Li Yuanyuan; Zhou Haiyan; Zhang Lei; Guan Su; (21 pag.)CN110078668; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary