Ruthenium-Catalyzed Intramolecular Hydroarylation of Arenes with Olefins in Water was written by Mukherjee, Kallol;Ramesh, E.;Ghosh, Koushik;Sahoo, Akhila K.. And the article was included in Asian Journal of Organic Chemistry in 2018.Reference of 192810-12-1 This article mentions the following:
Herein, A Ru-catalyzed intramol. hydroarylation of arenes I (R = H, 4-Me, 3-Br, etc.; R1 = Me; R2 = Me, Et; MPS = Me Ph sulfoximine) in an aqueous medium is presented. With the aid of Me Ph sulfoximine or an amide directing group, this atom-efficient hydroarylation of arenes ensued dihydrobenzofuran derivatives II (R = H, 5-Me, 6-OBn, etc.; R1 = Me; R2 = Me, Et; MPS = Me Ph sulfoximine). Sequential double hydroarylation of arene motifs resulted in highly peripheral-decorated heterocycles. Deuterium labeling studies and control experiments offer valuable information in understanding the reactivity and the mechanistic data. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Reference of 192810-12-1).
Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 192810-12-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary