Modular synthesis of stereodefined benzocyclobutene derivatives via sequential Cu- and Pd-catalysis was written by Talbot, Fabien J. T.;Zhang, Shibo;Satpathi, Bishnupada;Howell, Gareth P.;Perry, Gregory J. P.;Crisenza, Giacomo E. M.;Procter, David J.. And the article was included in ACS Catalysis in 2021.Application In Synthesis of 2-Bromo-4-(trifluoromethyl)benzaldehyde This article mentions the following:
Benzocyclobutenes (BCBs) are of growing interest in materials and medicinal chem., although general routes for their provision remain underexplored. A modular, divergent and stereoselective Cu- and Pd-catalyzed assembly/cyclization sequence allows the synthesis of densely functionalized BCBs, from readily accessible imine, allene and diboron precursors. Preliminary results have identified enantioselective conditions for this protocol, and highlighted, for example, its applicability to the synthesis of BCB-containing peptides. By simple variation of exptl. conditions or substrate modification, authors strategy was expanded to deliver indoline and quinoline derivatives, suitable for further manipulations. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Application In Synthesis of 2-Bromo-4-(trifluoromethyl)benzaldehyde).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application In Synthesis of 2-Bromo-4-(trifluoromethyl)benzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary