Huestis, Malcolm P. et al. published their research in ACS Medicinal Chemistry Letters in 2021 | CAS: 945244-29-1

5-Bromo-2-fluoro-4-methylaniline (cas: 945244-29-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 5-Bromo-2-fluoro-4-methylaniline

Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor was written by Huestis, Malcolm P.;Durk, Matthew R.;Eigenbrot, Charles;Gibbons, Paul;Hunsaker, Thomas L.;La, Hank;Leung, Dennis H.;Liu, Wendy;Malek, Shiva;Merchant, Mark;Moffat, John G.;Muli, Christine S.;Orr, Christine J.;Parr, Brendan T.;Shanahan, Frances;Sneeringer, Christopher J.;Wang, Weiru;Yen, Ivana;Yin, Jianping;Rudolph, Joachim;Siu, Michael. And the article was included in ACS Medicinal Chemistry Letters in 2021.Recommanded Product: 5-Bromo-2-fluoro-4-methylaniline This article mentions the following:

Structure-based optimization of a set of aryl urea RAF inhibitors has led to the identification of Type II pan-RAF inhibitor GNE-9815 (7)(I), which features a unique pyrido[2,3-d]pyridazin-8(7H)-one hinge-binding motif. With minimal polar hinge contacts, the pyridopyridazinone hinge binder moiety affords exquisite kinase selectivity in a lipophilic efficient manner. The improved physicochem. properties of GNE-9815 provided a path for oral dosing without enabling formulations. In vivo evaluation of GNE-9815 in combination with the MEK inhibitor cobimetinib demonstrated synergistic MAPK pathway modulation in an HCT116 xenograft mouse model. To the best of our knowledge, GNE-9815 is among the most highly kinase-selective RAF inhibitors reported to date. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-fluoro-4-methylaniline (cas: 945244-29-1Recommanded Product: 5-Bromo-2-fluoro-4-methylaniline).

5-Bromo-2-fluoro-4-methylaniline (cas: 945244-29-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 5-Bromo-2-fluoro-4-methylaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary