A facile approach for the total synthesis of neurotrophic diyne tetraol petrosiol A and petrosiol E was written by Gangadhar, Pamarthi;Sathish Reddy, A.;Srihari, Pabbaraja. And the article was included in Tetrahedron in 2016.Synthetic Route of C23H26BrP This article mentions the following:
The first total synthesis of neurotrophic diacetylenic tetraol, petrosiol A (I) and stereoselective total synthesis of petrosiol E (II) was accomplished. The total synthesis involves Cadiot-Chodkiewicz coupling reaction as the key step for petrosiol A. The diastereo-rich chiral alc. (third chiral center) was synthesized from CBS mediated stereoselective ketone reduction reaction for petrosiol E. Of the three chiral centers, the two chiral centers are originated from (+)-di-Et
Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Synthetic Route of C23H26BrP
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary