New enantiomeric fluorine-containing derivatives of sulforaphane: Synthesis, absolute configurations and biological activity was written by Kielbasinski, Piotr;Luczak, Jerzy;Cierpial, Tomasz;Blaszczyk, Jaroslaw;Sieron, Leslaw;Wiktorska, Katarzyna;Lubelska, Katarzyna;Milczarek, Malgorzata;Chilmonczyk, Zdzislaw. And the article was included in European Journal of Medicinal Chemistry in 2014.Name: N-(5-Bromopentyl)phthalimide This article mentions the following:
Three pairs of enantiomers of the unknown sulforaphane analogs, e.g. CF3S(O)(CH2)4NCS, bearing organofluorine substituents bonded to the sulfinyl sulfur atom and having different number of methylene groups in the central carbon chain were synthesized and fully characterized, including determination of their absolute configurations. All the new compounds were tested in vitro for their cytotoxicity against melanoma cells to show increased activity in comparison with the natural sulforaphane. The influence of the particular structural changes in the mol. on the cytotoxicity is discussed. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Name: N-(5-Bromopentyl)phthalimide).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Name: N-(5-Bromopentyl)phthalimide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary