Transport of Nucleoside Triphosphates into Cells by Artificial Molecular Transporters was written by Zawada, Zbigniew;Tatar, Ameneh;Mocilac, Pavle;Budesinsky, Milos;Kraus, Tomas. And the article was included in Angewandte Chemie, International Edition in 2018.Computed Properties of C42H63Br7O28 This article mentions the following:
Chem. modified nucleoside triphosphates (NTPs) are widely exploited as unnatural metabolites in chem. biol. and medicinal chem. Because anionic NTPs do not permeate cell membranes, their corresponding neutral precursors were employed in cell-based assays. These precursors become active metabolites after enzymic conversion, which often proceeds insufficiently. Metabolically-active NTPs can be directly transported into eukaryotic cells and bacteria by the action of designed synthetic nucleoside triphosphate transporters (SNTTs). The transporter is composed of a receptor, which forms a noncovalent complex with a triphosphate anion, and a cell-penetrating agent, which translocates the complex across the plasma membrane. NTP is then released from the complex in the intracellular milieu and accumulates in nuclei and nucleoli in high concentration The transport of NTPs proceeds rapidly (seconds to minutes) and selectively even in the presence of other organic anions. This operationally simple and efficient means of transport of fluorescently labeled NTPs into cells can be used for metabolic labeling of DNA in live cells. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Computed Properties of C42H63Br7O28).
Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Computed Properties of C42H63Br7O28
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary