Transannular Approach to 2,3-Dihydropyrrolo[1,2-b]isoquinolin-5(1H)-ones through Bronsted Acid-Catalyzed Amidohalogenation was written by Capel, Estefania;Luis-Barrera, Javier;Sorazu, Ana;Uria, Uxue;Prieto, Liher;Reyes, Efraim;Carrillo, Luisa;Vicario, Jose L.. And the article was included in Journal of Organic Chemistry in 2022.Related Products of 653-92-9 This article mentions the following:
A transannular approach has been developed for the construction of pyrrolo[1,2-b]isoquinolinones I (R1 = H, F, Cl, Me, OMe, etc.; R2 = H, F, etc.; R3 = H, Me, etc.; R4 = H, F) starting from benzo-fused nine-membered enelactams II. This process takes place in the presence of a halogenating agent and under Bronsted acid catalysis and proceeds via a transannular amidohalogenation, followed by elimination. The reaction has been found to be wide in scope, enabling the formation of a variety of tricyclic products I in good overall yield, regardless of the substitution pattern in the initial lactam substrate. The reaction has also been applied to the total synthesis of a reported topoisomerase I inhibitor and to the formal synthesis of rosettacin. Further extension of this methodol. allows the preparation of 10-iodopyrrolo[1,2-b]isoquinolinones III (R1 = H, Me; R2 = H, F; R3 = H, F, Me, OMe) by using an excess of halogenating agent and these compounds can be further manipulated through standard Suzuki coupling chem. into a variety of 10-aryl-substituted pyrrolo[1,2-b]isoquinolinones IV. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Related Products of 653-92-9).
Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Related Products of 653-92-9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary