Alkenylcopper reagents. 26. Carbocupration of alkynes by organocopper reagents bearing a protected hydroxy or thiol function was written by Gardette, M.;Alexakis, A.;Normant, J. F.. And the article was included in Tetrahedron in 1985.Name: 1-Bromo-6-methoxyhexane This article mentions the following:
Halohydrins, protected as ethers, acetals, or chloro-magnesium alcoholates were sequentially transformed to Li or Mg reagents, and then to copper or cuprate derivatives Addition of the copper reagents with alkynes was studied. Thus, treating Y(CH2)nX(Y = LiO, Me3SiO, Me3O, PhS, tetrahydropyranyl, etc.; X = Br, Cl; n = 3,4,6,8,10) with Li in Et2O gave Y(CH2)nLi. Treating the last with CuBr·Me2S in Et2O, followed by reaction with HCCH at -50°, followed by acid hydrolysis gave Y(CH2)nCH:CH2. Reactions of the copper or cuprate reagents with electrophiles was investigated. In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Name: 1-Bromo-6-methoxyhexane).
1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Name: 1-Bromo-6-methoxyhexane
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary