Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone was written by Miao, Wenjun;Zhao, Yanchuan;Ni, Chuanfa;Gao, Bing;Zhang, Wei;Hu, Jinbo. And the article was included in Journal of the American Chemical Society in 2018.Computed Properties of C16H17Br This article mentions the following:
In the presence of Fe(acac)3 and N,N,N’,N’-tetramethylethylenediamine, arylzinc reagents (in most cases generated in situ from aryl Grignard reagents) underwent difluoromethylation reactions with difluoromethyl 2-pyridinyl sulfone at -40° to ambient temperature to yield difluoromethylarenes. Reaction of a difluoropentenyl 2-pyridinyl sulfone with an in situ-generated diarylzinc reagent yielded an arylmethyldifluorocyclopentane, implying the involvement of radical species in the iron-catalyzed difluoromethylation; the reaction was inhibited by TEMPO, BHT, and 1,4-dinitrobenzene. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Computed Properties of C16H17Br).
4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C16H17Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary