Synthesis of Fluorinated Acridines via Sequential Micellar Buchwald-Hartwig Amination/Cyclization of Aryl Bromides was written by Vaghi, Luca;Sanzone, Alessandro;Sassi, Mauro;Pagani, Simone;Papagni, Antonio;Beverina, Luca. And the article was included in Synthesis in 2018.Computed Properties of C8H4BrF3O This article mentions the following:
Fluorinated unsym. acridines were efficiently prepared by means of a tandem micellar Buchwald-Hartwig amination followed by an acid-promoted cyclization. The overall process was advantageous with respect to previously described protocols both in terms of efficiency and sustainability. The role of the cosolvent in the amination step was highlighted, demonstrating that rather than resorting to highly expensive catalysts, Buchwald-Hartwig aminations could be straightforwardly carried out by tuning the reaction site polarity. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Computed Properties of C8H4BrF3O).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C8H4BrF3O
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary