Palladium-catalyzed N-arylation of 2-aminobenzothiazole-4-carboxylates/carboxamides: facile synthesis of PARP14 inhibitors was written by Wang, Pingyuan;Li, Jian;Jiang, Xue;Liu, Zhiqing;Ye, Na;Xu, Youjun;Yang, Guangfu;Xu, Yechun;Zhang, Ao. And the article was included in Tetrahedron in 2014.Formula: C8H6BrFO2 This article mentions the following:
We have developed a palladium-catalyzed N-arylation of the biol. interesting, but synthetically rather challenging 2-arylaminobenzothiazoles bearing multiple functionalities. This protocol was successfully used to readily synthesize our initial PARP14 inhibitor followed by a limited structural optimization. A more potent PARP14 inhibitor with an IC50 value of 1.69 μM was identified, and the interaction was ascertained by the X-ray co-crystal structure of the catalytic domain of PARP14 in complex with compound I. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Formula: C8H6BrFO2).
Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C8H6BrFO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary