Screening of bromotyramine analogues as antifouling compounds against marine bacteria was written by Andjouh, Sofyane;Blache, Yves. And the article was included in Biofouling in 2016.Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:
Rapid and efficient synthesis of 23 analogs inspired by bromotyramine derivatives, marine natural products, by means of CuSO4-catalyzed [3+2] alkyne-azide cycloaddition is described. The final target was then assayed for anti-biofilm activity against three Gram-neg. marine bacteria, Pseudoalteromonas ulvae (TC14), Pseudoalteromonas lipolytica (TC8) and Paracoccus sp. (4M6). Most of the synthesized bromotyramine/triazole derivatives are more active than the parent natural products Moloka’iamine () and 3,5-dibromo-4-methoxy-β-phenethylamine () against biofilm formation by the three bacterial strains. Some of these compounds were shown to act as non-toxic inhibitors of biofilm development with EC50 < 200 μM without any effect on bacterial growth even at high concentrations (200 μM). In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene).
1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary