An amine template strategy to construct successive C-C bonds: synthesis of benzo[h]quinolines by a deaminative ring contraction cascade was written by McFadden, Timothy Patrick;Nwachukwu, Chideraa Iheanyi;Roberts, Andrew George. And the article was included in Organic & Biomolecular Chemistry in 2022.Safety of 2-Bromo-4-fluorobenzylbromide This article mentions the following:
A convergent strategy to build, cyclize and excise nitrogen from tertiary amines for the synthesis of polyheterocyclic aromatics was developed. Biaryl-linked azepine intermediates underwent a deaminative ring contraction cascade reaction, excising nitrogen with the formation of an aromatic core. This strategy and deaminative ring contraction reaction was useful for the synthesis of benzo[h]quinolines. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Safety of 2-Bromo-4-fluorobenzylbromide).
2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Safety of 2-Bromo-4-fluorobenzylbromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary