Cobalt carbonyl catalyzed selective mono-carbonylation of halobenzyl halides. I. was written by Shim, Sang Chul;Doh, Chil Hoon;Yoon, Young Zoo;Cho, Chan Sik;Woo, Byung Won. And the article was included in Taehan Hwahakhoe Chi in 1990.Product Details of 2178-24-7 This article mentions the following:
A method for regioselective mono-carbonylation of halobenzyl halides is described. Alkyl halophenylacetate is easily prepared by carbonylating a halobenzyl halide in the presence of a catalytic amount of cobalt carbonyl, a base, and an alc. under atm. pressure of carbon monoxide. The base plays a decisive role in the selectivity of product, and NEt3 is the best one among bases used. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Product Details of 2178-24-7).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 2178-24-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary