Synthesis and evaluation of anti-microbial and analgesic activity of some (4Z)-3-methyl-1-[(2-oxo-2H-chromen-4-yl) carbonyl]-1H-pyrazole-4,5-dione substitutedphenyl) hydrazone] was written by Sivakumar, K. K.;Rajasekaran, A.;Ponnilavarasan, I.;Somasundaram, A.;Sivasakthi, R.;Kamalaveni, S.. And the article was included in Pharmacia Lettre in 2010.Application of 615-55-4 This article mentions the following:
A series of (4Z)-3-methyl-1-[(2-oxo-2H-chromen-4-yl) carbonyl]-1H-pyrazole-4,5-dione 4-[(4-substitutedphenyl)hydrazone] (5a-i) have been synthesized. All the synthesized compounds were characterized on the basis of elemental anal. and spectral data (IR, 1HNMR). The titled compounds were screened for their anti-inflammatory and analgesic activity. Among the synthesized compounds, compound 5a, 5c, 5g and 5h exhibited significant anti-microbial activity and compound 5a, 5b, 5d, 5h, and 5i exhibited significant analgesic activity compared with the standard drug (indomethacin 5 mg/kg) at the dose level of 50 mg/kg on oral administration. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Application of 615-55-4).
3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 615-55-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary