Regio- and Stereoselective Synthesis of Ynenamides through Gold(I)-Catalyzed Hydroalkynylation of Ynamides was written by Siera, Hannah;Kreuzahler, Mathis;Wolper, Christoph;Haberhauer, Gebhard. And the article was included in European Journal of Organic Chemistry in 2022.COA of Formula: C4H4BrNO2 This article mentions the following:
Herein, regio- and stereoselective preparation of ynenamides I [R = Pr, cyclopropyl, Ph, etc.] via gold(I)-catalyzed hydroalkynylation of ynamides was exptl. shown. A wide range of products could be generated with yields up to 90% and, in contrast to many other gold-catalyzed alkyne dimerization reactions, alkyl groups were tolerated. Quantum chem. calculations and NMR labeling experiments revealed a mechanism via dual gold catalysis. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5COA of Formula: C4H4BrNO2).
1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.COA of Formula: C4H4BrNO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary