Side chain methyl analogs of Δ8-THC was written by Huffman, John W.;Lainton, Julia A. H.;Banner, W. Kenneth;Duncan, Sammy G. Jr.;Jordan, Robert D.;Yu, Shu;Dai, Cong;Martin, Billy R.;Wiley, Jenny L.;Compton, David R.. And the article was included in Tetrahedron in 1997.Safety of Isopentyltriphenylphosphonium bromide This article mentions the following:
The synthesis of both side chain epimers of 1′- (I; R = CHMeBu) 2′- (I; R = CH2CHMePr) and 3′-Me- [I; R = (CH2)2CHMeEt] and 4′-methyl-Δ8-tetrahydrocannabinol [I; R = (CH2)3CHMe2] was carried out. The synthetic approach entailed the acid catalyzed condensation of the appropriate substituted resorcinol with menthadienol to provide the analog of Δ8-THC [I; R = (CH2)4Me]. Both isomers of 1′-Me- (I; R = CHMeBu) and 2′-Me-Δ8-THC (I; R = CH2CHMePr) were more potent than Δ8-THC , both in vitro and in vivo. The 3′-Me isomers (I; R = CH2CH2CHMeEt) were approx. equal in potency to Δ8-THC, and 4′-methyl-Δ8-THC was less potent. There was relatively little difference in potency between the epimers of I (R = CHMeBu, CH2CHMePr, CH2CH2CHMeE). In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Safety of Isopentyltriphenylphosphonium bromide).
Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of Isopentyltriphenylphosphonium bromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary