Novel polycyclic heterocycles. XI. Synthesis of 11,12-dihydropyrido[2,1-b][1,3]benzodiazepines, 6H-pyrido[1,2-c][1,3,5]benzoxadiazepines, and 6H-pyrido[1,2-c][1,3,5]benzothiadiazepines was written by Petigara, R. B.;Yale, Harry L.. And the article was included in Journal of Heterocyclic Chemistry in 1974.Category: bromides-buliding-blocks This article mentions the following:
An unusually facile dehydrobromination, involving the ortho Br atom and the NH proton of the iminopyridines I (X = CH2, O, S, R = H, Cl) gave the 11,12-dihydropyrido[2,1-b] [1,3]benzodiazepines II (X = CH2), 6H-pyrido[1,2-c] [1,3,5]benzoxadiazepines II (X = O), and 6H-pyrido-[1,2-c] [1,3,5]benzothiadiazepines II (X = S). These cyclizations required a base, e.g., potassium carbonate, and a catalyst, e.g., copper bronze. The reactions occurred in methanol or propanol at reflux, either under anhydrous conditions or in the presence of large amounts of water. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Category: bromides-buliding-blocks).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary