Parallel Synthesis of Glycomimetic Libraries: Targeting a C-Type Lectin was written by Schuster, Michael C.;Mann, David A.;Buchholz, Tonia J.;Johnson, Kathryn M.;Thomas, William D.;Kiessling, Laura L.. And the article was included in Organic Letters in 2003.Reference of 6515-58-8 This article mentions the following:
We have developed methods for the parallel synthesis of two libraries of non-carbohydrate-based analogs of mannose on a solid support. The natural product shikimic acid was used as a key building block. The ability of the compounds to block the binding of the C-type lectin MBP-A to a mannosylated surface was assessed in a high-throughput assay. Ten library members with inhibitory activities equivalent to that of α-Me mannopyranoside were identified. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Reference of 6515-58-8).
3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Reference of 6515-58-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary