Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 53784-83-1
Synthesis, characterization, and remarkable biological properties of cyclodextrins bearing guanidinoalkylamino and aminoalkylamino groups on their primary side was written by Mourtzis, Nikolaos;Paravatou, Maria;Mavridis, Irene M.;Roberts, Michael L.;Yannakopoulou, Konstantina. And the article was included in Chemistry – A European Journal in 2008.HPLC of Formula: 53784-83-1 This article mentions the following:
The introduction of aminoalkylamino and guanidinoalkylamino substituents on the primary side of β- and γ-cyclodextrin (CDs) resulted in a series of novel compounds that were extensively characterized by NMR spectroscopy and mass spectrometry. Bromination of the primary side of β- and γ-CD, and reaction with neat alkylene diamines at a pressure of 7 atm afforded aminoalkylamino derivatives that were then guanylated at the primary amino group to give the corresponding guanidinoalkylamino-CDs. These compounds are water soluble and display pKa values that allow them to be mostly protonated at neutral pH; for example, pKa1 â?.4 and pKa2 â?.5 for the aminoethylamino-β-CD and pKa1 â?.8 and pKa2 â?1.0 for the guanidinoethylamino-β-CD. The title CDs are rigid, cyclic α-D-glucopyranose oligomers (heptamers or octamers) with branches that resemble lysine and arginine side chains that enable multiple interactions with suitable substrates. Thus, they bear similarities to known cell-penetrating peptides. Indeed, the compounds were found to cross the membranes of HeLa cells and penetrate inside the cytoplasm quickly, the guanidinylated ones within 15 min, as shown by fluorescence microscopy using fluorescein-labeled derivatives The toxicity of the compounds, measured by performing MTT tests, ranged from 50 to 300 μM. Furthermore, some of the aminated CDs could facilitate the transfection of DNA expressing the green fluorescent protein (GFP) in HEK 293T cells, with effectiveness comparable to the com. agent Lipofectamine 2000. CD, at. force microscopy and electrophoresis experiments confirmed the strong interaction of the compounds with DNA. Because of their carbohydrate, non-peptide nature the title compounds are not anticipated to be enzymically labile or immunogenic, and thus they fulfill many of the criteria for non-hazardous transport vectors in biol. and pharmaceutical applications. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1HPLC of Formula: 53784-83-1).
Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 53784-83-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary