Nitric Oxide-Releasing Cyclodextrins was written by Jin, Haibao;Yang, Lei;Ahonen, Mona Jasmine R.;Schoenfisch, Mark H.. And the article was included in Journal of the American Chemical Society in 2018.Synthetic Route of C42H63Br7O28 This article mentions the following:
A series of secondary amine-modified cyclodextrin (CD) derivatives were synthesized with diverse exterior terminal groups (i.e., hydroxyl, Me, methoxyl, and primary amine). Subsequent reaction with nitric oxide (NO) gas under alk. conditions yielded N-diazeniumdiolate-modified CD derivatives Adjustable NO payloads (0.6-2.4 μmol/mg) and release half-lives (0.7-4.2 h) were achieved by regulating both the amount of secondary amine precursors and the functional groups around the NO donor. The bactericidal action of these NO-releasing cyclodextrin derivatives was evaluated against Pseudomonas aeruginosa, a Gram-neg. pathogen with antibacterial activity proving dependent on both the NO payload and exterior modification. Materials containing a high d. of NO donors or primary amines exhibited the greatest ability to eradicate P. aeruginosa. Of the materials prepared, only the primary amine-terminated hepta-substituted CD derivatives exhibited toxicity against mammalian L929 mouse fibroblast cells. The NO donor-modified CD was also capable of delivering promethazine, a hydrophobic drug, thus demonstrating potential as a dual-drug releasing therapeutic. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1Synthetic Route of C42H63Br7O28).
Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C42H63Br7O28
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary