pKa Values and Geometries of Secondary and Tertiary Amines Complexed to Boronic Acids-Implications for Sensor Design was written by Wiskur, Sheryl L.;Lavigne, John J.;Ait-Haddou, Hassan;Lynch, Vincent;Chiu, Yu Hung;Canary, James W.;Anslyn, Eric V.. And the article was included in Organic Letters in 2001.Application of 166821-88-1 This article mentions the following:
The pKa values and the geometries of secondary and tertiary amines adjacent to boronic acids (e.g. 2-(PhCH2NRCH2)C6H4B(OH)2; R = H, Me) were determined using potentiometric and 11B NMR titrations The studies showed that the secondary ammonium ion has a pKa similar to that of the tertiary ammonium species, which gives tetrahedral B centers at pH values â?.5. Therefore, secondary amines as well as tertiary amines, when placed proximal to B centers, can be used to create tetrahedral boronic acids at neutral pH for diol complexation. The mol. structure of 2,6-(2-(2-((HO)2B)C6H4CH2NHCH2)-4-pyrimidinyl)2pyridine was determined by x-ray crystallog. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1Application of 166821-88-1).
2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 166821-88-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary