Carbonylative cycloaddition between two different alkenes enabled by reactive directing groups: expedited construction of bridged polycyclic skeletons was written by Gao, Bingjian;Zou, Suchen;Yang, Guoqing;Ding, Yongzheng;Huang, Hanmin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Name: 2-Bromo-4-(trifluoromethyl)benzaldehyde This article mentions the following:
A novel palladium-catalyzed highly selective hydrocarbonylative cycloaddition reaction with two different alkenes in the presence of CO enabled by a reactive directing-group is developed, which offered efficient and convenient access to lactone-containing bridged polycyclic compounds in high yield with high chemo- and stereoselectivities. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Name: 2-Bromo-4-(trifluoromethyl)benzaldehyde).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Name: 2-Bromo-4-(trifluoromethyl)benzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary