Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors was written by Congdon, Molly D.;Kharel, Yugesh;Brown, Anne M.;Lewis, Stephanie N.;Bevan, David R.;Lynch, Kevin R.;Santos, Webster L.. And the article was included in ACS Medicinal Chemistry Letters in 2016.Name: 1-Bromo-4-methoxybutane This article mentions the following:
The two isoforms of sphingosine kinase (SphK1 and SphK2) are the only enzymes that phosphorylate sphingosine to sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in a broad range of cellular processes including migration, proliferation, and inflammation. SphKs are targets for various diseases such as cancer, fibrosis, and Alzheimer’s and sickle cell disease. Herein, the authors disclose the structure-activity profile of naphthalene-containing SphK inhibitors, e.g. I, and mol. modeling studies that reveal a key mol. switch that controls SphK selectivity. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Name: 1-Bromo-4-methoxybutane).
1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 1-Bromo-4-methoxybutane
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary