Substituted caffeic and ferulic acid phenethyl esters: synthesis, leukotrienes biosynthesis inhibition and cytotoxic activity was written by Morin, Pier Jr.;St-Coeur, Patrick-Denis;Doiron, Jeremie A.;Cormier, Marc;Poitras, Julie J.;Surette, Marc E.;Touaibia, Mohamed. And the article was included in Molecules in 2017.Electric Literature of C9H11BrO This article mentions the following:
A series of caffeic and ferulic acid esters bearing addnl. oxygens moieties (OH or OCH3) were designed and synthesized. Polyphenolic compounds, including caffeic acid phenethyl ester (CAPE) was investigated for their anticancer properties in several types of cancer while ferulic acid phenethyl ester (FAPE) displayed substantial cytotoxicity against two glioma cell lines. Some selected compounds derived from both (CAPE) and (FAPE) also displayed cytotoxicity. All CAPE-derived compounds were able to significantly inhibit 5-lipoxygenase (5-LO), however FAPE-derived compounds were largely ineffective 5-LO inhibitors. Mol. docking revealed new hydrogen bonds and π-π interactions between the enzyme and some of the investigated compounds Overall, this work highlighted the relevance of exploring polyphenolic compounds in cancer models and provides addnl. led in the development of novel therapeutic strategies in gliomas. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Electric Literature of C9H11BrO).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C9H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary