Intramolecular Pd-Catalyzed Reductive Amination of Enolizable sp3-C-H Bonds was written by Ford, Russell L.;Alt, Isabel;Jana, Navendu;Driver, Tom G.. And the article was included in Organic Letters in 2019.Computed Properties of C7H5BrFNO2 This article mentions the following:
A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp3-C-NHAr bonds from sp3-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol % of Pd(OAc)2 and 10 mol % of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles I (R1 = H, Cl, Me, etc.; R2 = H, F, Me, etc.; R3 = H, Me) using α-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Computed Properties of C7H5BrFNO2).
1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C7H5BrFNO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary