MeOTf-Catalyzed Intramolecular Acyl-Cyclization of Aryl Isocyanates: Efficient Access to Phenanthridin-6(5H)-one and 3,4-Dihydroisoquinolin-1(2H)-one Derivatives was written by Zou, Song;Zhang, Zeyu;Chen, Chao;Xi, Chanjuan. And the article was included in Asian Journal of Organic Chemistry in 2021.Formula: C9H11BrO This article mentions the following:
MeOTf-catalyzed intramol. acyl-cyclization of aryl isocyanates has been realized to provide (NH)-phenanthridinones and lactams under metal-free conditions. A variety of functional groups are tolerated in their scaffolds with good to excellent yields. The reaction could be carried to gram scale and a range of natural alkaloids, such as crinasiadine, benzophenidine alkaloid (ZYH005), N-methylcrinasiadine, and trisphaeridine could be synthesized directly or in short steps with high yields. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Formula: C9H11BrO).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Formula: C9H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary