Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 179232-29-2
Impact of Entropic Effects in the Classical Resolution of a 2-Arylpyrrolidine was written by Barnes, David M.;Barkalow, Jufang;Chen, Yong;Gupta, Ashok;Haight, Anthony R.;Hengeveld, John E.;Kerdesky, Francis A. J.;Kotecki, Brian J.;Macri, Bryan;Pal, Agnes. And the article was included in Organic Process Research & Development in 2009.Product Details of 179232-29-2 This article mentions the following:
The impact of entropic effects on the classical salt resolution of a 2-arylpyrrolidine I·D-tartrate is described. The crystallization of a racemic mixture of the base with tartaric acid led to a salt in which the undesired enantiomer is incorporated into the crystal lattice as a solid solution The product enantiomer ratio was later determined to be at the thermodn. well when the racemate is crystallized In order to circumvent this effect, an efficient two-crystallization resolution was developed. The bulk of the undesired enantiomer is removed in the first crystallization so that the second crystallization can result in material of acceptable optical purity. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Product Details of 179232-29-2).
Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 179232-29-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary