Podands with 10-ethyl-3,7-dithienyl-10H-phenothiazine core: synthesis and structural analysis was written by Petran, Anca;Bogdan, Elena;Terec, Anamaria;Grosu, Ion. And the article was included in Revue Roumaine de Chimie in 2012.Quality Control of 5-Bromothiophene-3-carbaldehyde This article mentions the following:
New podands showing substituted thiophene groups connected to positions 3 and 7 of a central 10-ethyl-10H-phenothiazine unit were obtained in good yield by cross-coupling reaction strategy. The thiophene rings are substituted either with formyl or hydroxymethyl groups, either at position 4′ or at position 5′. These podands can participate by various reactions to the enclosure of macrocyclic compounds and the reported compounds are versatile precursors for host mols. embedding thiophene and phenothiazine moieties. The structure of the podands was investigated by NMR and MS spectra. The title compounds thus formed included a dimethanol (I) and alc. regioisomer analog (II). The synthesis of the target compounds was achieved using 10-ethyl-3,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-10H-phenothiazine, 3,7-dibromo-10-ethyl-10H-phenothiazine as starting materials. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Quality Control of 5-Bromothiophene-3-carbaldehyde).
5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Quality Control of 5-Bromothiophene-3-carbaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary