The induction of chromosome aberrations in Vicia faba by halogenated butyl ethers was written by Michaelis, A.;Rieger, R.;Sieber, G.. And the article was included in Biologisches Zentralblatt in 1964.Electric Literature of C5H11BrO This article mentions the following:
Treatment with 10-4 – 64 × 10-4M Me 4-bromobutyl ether (I), 10-4 – 60 × 10-4M, Et 4-bromobutyl ether (II), 5 × 10-5 – 10-4 4,4′-dichlorodibutyl ether (III), and 5 × 10-5 – 10-4 4,4′ dibromodibutyl ether (IV) for 1-24 hrs. at pH 7, followed by 0.05% colchicine treatment provoked chromatid types of chromosome aberrations in V. faba roots, localized in the heterochromatic regions. The degree of mutagenic activity was IV > I > II > III. It is suggested that I-IV and N mustard have similar mechanism of mutagenic activity. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Electric Literature of C5H11BrO).
1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Electric Literature of C5H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary